Influence of Titanium Dioxide Grain Size on Phasic Composition and Lysozyme Adsorption of Hydroxyapatite and Titanium Dioxide Composite Powders—A Thermal Decomposition Study by XRD and SEM Analysis

Abstract Biomedical applications make high demands on the development of novel bioactive materials, which are often based functionalized calcium phosphates (CaPs). In this study, pure nanoscaled hydroxyapatite (HAp) and modified HAp with titanium dioxide (TiO 2 ) both nano‐ microparticles successfully synthesized from reactants hydroxide orthophosphoric acid in a wet chemistry reaction. The obtained powders sintered temperature range 750 °C–1400 °C to study their thermal decomposition behavior. phase composition surface morphology characterized using X‐ray diffraction, scanning electron microscopy, energy dispersive spectroscopy element mapping. Lysozyme adsorption experiments reveal significantly higher samples nanoparticles. Sintered TiO particle sizes show β‐tricalcium phosphate (β‐TCP) as well formation perovskite (CaTiO 3 different portions depending size. nanoparticles support anatase rutile transformation at lower temperatures than microparticles. results that examined HAp/TiO composites may serve starter material for tailormade biomaterials specific by variation sintering